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While they will go away on their own, most of us seek out the best over-the-counter cold sore medicine. recommendations for genital herpes state oral antiviral therapy is preferred over topical antiviral therapy. All you need for a cold sore is an over the counter cream or antiviral medication. List of Herpes Treatments:. Some are over-the-counter medicines, while others must be prescribed by your doctor. Over the counter treatment of herpes zoster involves the use of nonsteroidal anti-inflammatory drugs like ibuprofen and naproxen. Likewise, there’s also no shortage of over-the-counter cold sore meds, which include things like medicated ointments (Blistex, Carmex, etc), zinc oxide creams, Orajel (which is a numbing cream), and Zilactin. They're only effective if you apply them as soon as the first signs of a cold sore appear, when the herpes simplex virus is spreading and replicating. 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Notoriously difficult get rid of, cold sores are normally treated with anti-viral creams bought over the counter. To be effective, these treatments should be applied as soon as the first signs of a cold sore appear. Topical acyclovir comes as a cream and an ointment to apply to the skin. Prescription medications that are indicated to treat cold sores all contain antivirals, which attack the HSV-1 virus itself. Moreover, the longer you have had the virus, the less painful and frequent the outbreaks are likely to be. Most commonly prescribed medicine in herpes outbreak is acyclovir only. Hi Kare Brown, I know you asked your question a long time ago, but I was wondering if. Over-The-Counter Cold Sore Medicine - apply Category New Blistex Antiviral Cold Sore Cream. It stops the growth of certain viruses. It helps your immune system keep the infection controlled, although it does not heal the infection. coreinternational. 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Some of the most accessible and reliable natural antiviral herbs: Astragalus (astragalus membranaceus): has been in the Chinese Materia Medica for centuries and has shown to have immune boosting properties. These are also over the counter medicines, but they have no side-effects as compared to herpes prescribed medicines. Over the Counter. Antiviral medicines can be taken just during an outbreak, starting as soon as the first signs are noticed (episodic treatment), or they can be taken continuously (even when there are no symptoms) to reduce the chance of having repeat outbreaks (suppressive treatment). Prescription medications that are indicated to treat cold sores all contain antivirals, which attack the HSV-1 virus itself. Capsaicin Cream ; The first is an over the counter cream similar to the capsaicin skin patches that your doctor can administer. 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